N=6 superconformal Chern-Simons-matter theories, M2-branes and their gravity duals

We construct three dimensional Chern-Simons-matter theories with gauge groups U(N)xU(N) and SU(N)xSU(N) which have explicit N=6 superconformal symmetry. Using brane constructions we argue that the U(N)xU(N) theory at level k describes the low energy limit of N M2-branes probing a C^4/Z_k singularity. At large N the theory is then dual to M theory on AdS_4xS^7/Z_k. The theory also has a 't Hooft limit (of large N with a fixed ratio N/k) which is dual to type IIA string theory on AdS_4xCP^3. For k=1 the theory is conjectured to describe N M2-branes in flat space, although our construction realizes explicitly only six of the eight supersymmetries. We give some evidence for this conjecture, which is similar to the evidence for mirror symmetry in d=3 gauge theories. When the gauge group is SU(2)xSU(2) our theory has extra symmetries and becomes identical to the Bagger-Lambert theory.Comment: 41 pages, 4 figures. v3: minor corrections, added references. v4: added reference, minor changes, JHEP versio

The effect of personality traits on file retrieval

File retrieval is important for Personal Information Management (PIM). If retrieval fails, people cannot re-use files that they created or other people shared with them. In this paper, we examined the effect of personality traits on retrieval success and efficiency in two studies. Study 1 (n = 60) examined the effect of the Big Five personality traits. Study 2 (n = 300) evaluated the effect of other personality traits that we hypothesized would improve retrieval: need for control, orderliness, memory, computer literacy, minimalism, stress resistance, sociability and empathy. None of the tests we conducted were significant, meaning that even if future effects are identified, they will most probably be weak. In contrast, significant effects on retrieval success and efficiency were previously found for factors such as: sharing method, file collection size, number of collaborators sharing the file, file versions, recency since last retrieval, folder depth and workload. Nevertheless, the null-results we report here are important because the failure to publish non-significant results can have a negative influence on re-search. Otherwise these effects may be repeatedly studied until significant results emerge and are published, possibly because of a type I error

Easy on that trigger dad: a study of long term family photo retrieval

We examine the effects of new technologies for digital photography on people's longer term storage and access to collections of personal photos. We report an empirical study of parents' ability to retrieve photos related to salient family events from more than a year ago. Performance was relatively poor with people failing to find almost 40% of pictures. We analyze participants' organizational and access strategies to identify reasons for this poor performance. Possible reasons for retrieval failure include: storing too many pictures, rudimentary organization, use of multiple storage systems, failure to maintain collections and participants' false beliefs about their ability to access photos. We conclude by exploring the technical and theoretical implications of these findings

Insulin-Like Growth Factor-Binding Protein 7 Regulates Keratinocyte Proliferation, Differentiation and Apoptosis

Insulin-like growth factor (IGF)-binding protein 7 (IGFBP7) belongs to the IGFBP superfamily, which is involved in the regulation of IGF and insulin signaling. Recently, a global gene expression study revealed that IGFBP7 is downregulated in the psoriatic epidermis, with UVB phototherapy restoring its expression to normal. In the present study, we confirmed that IGFBP7 expression is decreased in psoriatic lesions. Given the previous data suggesting a role for IGFBP7 in the control of cancer cell growth, we investigated its involvement in the regulation of keratinocyte (KC) proliferation and differentiation, which are abnormal in psoriasis. To model IGFBP7 downregulation in vitro, we used IGFBP7-specific small interfering RNA or small hairpin RNA-expressing lentiviral vectors in HaCaT cells or primary human KCs. Downregulation of IGFBP7 was found to markedly enhance KC proliferation in both systems, was associated with a significant decrease in KC susceptibility to tumor necrosis factor-α-induced apoptosis, but did not affect senescence. Downregulation of IGFBP7 was also shown to block expression of genes associated with calcium-induced differentiation of human KCs. Finally, recombinant IGFBP7 was found to inhibit KC proliferation and enhanced their apoptosis. These data position IGFBP7 as a regulator of KC proliferation and differentiation, suggesting a potential role for this protein in the pathophysiology and treatment of hyperproliferative dermatoses such as psoriasis

Socio-technical lifelogging: deriving design principles for a future proof digital past

Lifelogging is a technically inspired approach that attempts to address the problem of human forgetting by developing systems that ‘record everything’. Uptake of lifelogging systems has generally been disappointing, however. One reason for this lack of uptake is the absence of design principles for developing digital systems to support memory. Synthesising multiple studies, we identify and evaluate 4 new empirically motivated design principles for lifelogging: Selectivity, Embodiment, Synergy and Reminiscence. We first summarise 4 empirical studies that motivate the principles, then describe the evaluation of 4 novel systems built to embody these principles. The design principles were generative, leading to the development of new classes of lifelogging system, as well as providing strategic guidance about how those systems should be built. Evaluations suggest support for Selection and Embodiment principles, but more conceptual and technical work is needed to refine the Synergy and Reminiscence principles

The Moduli Space and M(atrix) Theory of 9d N=1 Backgrounds of M/String Theory

We discuss the moduli space of nine dimensional N=1 supersymmetric compactifications of M theory / string theory with reduced rank (rank 10 or rank 2), exhibiting how all the different theories (including M theory compactified on a Klein bottle and on a Mobius strip, the Dabholkar-Park background, CHL strings and asymmetric orbifolds of type II strings on a circle) fit together, and what are the weakly coupled descriptions in different regions of the moduli space. We argue that there are two disconnected components in the moduli space of theories with rank 2. We analyze in detail the limits of the M theory compactifications on a Klein bottle and on a Mobius strip which naively give type IIA string theory with an uncharged orientifold 8-plane carrying discrete RR flux. In order to consistently describe these limits we conjecture that this orientifold non-perturbatively splits into a D8-brane and an orientifold plane of charge (-1) which sits at infinite coupling. We construct the M(atrix) theory for M theory on a Klein bottle (and the theories related to it), which is given by a 2+1 dimensional gauge theory with a varying gauge coupling compactified on a cylinder with specific boundary conditions. We also clarify the construction of the M(atrix) theory for backgrounds of rank 18, including the heterotic string on a circle.Comment: 43 pages, 7 figures, JHEP format. v3: typos correcte

Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep

A defining feature of sleep is reduced responsiveness to external stimuli, but the mechanisms mediating sensory-evoked arousal remain unclear. We hypothesized that reduced locus coeruleus (LC) norepinephrine (NE) activity during sleep mediates unresponsiveness, and its action promotes sensory-evoked awakenings. We tested this using electrophysiological, behavioral, pharmacological, and optogenetic techniques alongside auditory stimulation in freely behaving rats. We found that systemic reduction in NE signaling lowered probability of sound-evoked awakenings (SEAs). The level of tonic LC activity during sleep anticipated SEAs. Optogenetic LC activation promoted arousal as evident in sleep-wake transitions, EEG desynchronization, and pupil dilation. Minimal LC excitation before sound presentation increased SEA probability. Optogenetic LC silencing using a soma-targeted anion-conducting channelrhodopsin (stGtACR2) suppressed LC spiking and constricted pupils. Brief periods of LC opto-silencing reduced the probability of SEAs. Thus, LC-NE activity determines the likelihood of sensory-evoked awakenings, and its reduction during sleep constitutes a key factor mediating behavioral unresponsiveness.This work was supported by the Israel Science Foundation (ISF) grants 1326/15 and 51/11 (I-CORE cognitive sciences) and the Adelis Foundation (to Y.N.). E.J.K. is an INSERM fellow. O.Y. is supported by the European Research Council (ERC-2013-StG OptoNeuromod 337637) and the Adelis Foundation. CAV2 vector production was supported by CNRS BioCampus (Montpellier). A.S. is a Wellcome Trust-funded PhD student on the Neural Dynamics program. A.J.K. is supported by the ISF grant 762/16 and the European Society of Anaesthesiology young investigator startup gran